Isolation of Metallo Beta Lactamases from Clinical Sample (MBL)

Heterogeneity of metallo-beta-lactamases in clinical isolates of Chryseobacterium meningosepticum from Hangzhou, China.

OBJECTIVES To determine the distribution and heterogeneity of metallo-beta-lactamases (MBLs) responsible for imipenem resistance in Chryseobacterium meningosepticum. METHODS Clinical C. meningosepticum isolates (n = 170) were collected from hospitals in Hangzhou, China. Production of MBLs was investigated by determination of imipenem MICs, and by using both a three-dimensional test and a 2-me...

Emergence of metallo-beta-lactamases in Acinetobacter spp clinical isolates from Argentina.

64 Rev Esp Quimioter 2010;23(2):100-102 The class B metallo carbapenem-hydrolyzing ß lactamases (MBLs) are enzymes of great concern because they possess activity against all ß -lactams, except monobactams. Up to now, several members of this family of enzymes have been described (IMP, VIM, SPM-1, GIM-1, SIM-1). Most of VIM and IMP genes usually reside within class 1 integrons as gene cassettes. ...

Prevalence of IMP and VIM Metallo-Beta-Lactamases in Pseudomonas aeruginosa Isolates from Clinical and Environmental Specimens in Intensive Care Units (ICUs) of Rasht Hospitals, Iran

Introduction: Pseudomonas aeruginosa is one of the leading causes of nosocomial infections, and antibiotic resistance of this pathogen is an important concern in treating such infections. The current work was conducted to investigate the prevalence of bla-IMP, and bla-VIM metallo-beta-lactamase (MBL) among clinical and environmental P. aeruginosa isolates obtained from ICUs of different hospita...

Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa

BACKGROUND Carbapenems are important drugs used for the treatment of Pseudomonas aeruginosa infections, however metallo-β-lactamases (MBL) are able to efficiently hydrolyze these classes of drugs. Immediate detection of the MBL-producing P. aeruginosa is necessary in order to accurately treat infections caused by this organism. OBJECTIVES To determine the prevalence of MBL producing P. aerugi...

Phenotypic and Genotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii